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Monday, 03 March 2008 05:36 Written by AHCS Team
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Glutamine is the most abundant amino acid in the
body. It is an important energy source for intestinal cells
(enterocytes) and is key for repair and replacement of enterocytes.
Glutamine levels decrease during periods of metabolic stress, such as during viral infections.
It is often found to be at lower than normal levels in people with chronic viral conditions and gastrointestinal disorders.
Glutamine is also a precursor of several other amino acids such as
glutathione, Glutamine also helps to build new tissue proteins by
slowing down tissue breakdown (catabolism).
Loss of lean body tissue is a well-accepted predictor of morbidity and
mortality from degenerative diseases. This function makes glutamine an
important supplement for anyone at risk of muscle wasting, and makes it
a favorite among athletes and body builders wishing to increase muscle
mass.
One of the principal uses of glutamine in HCV is to improve
overall gastrointestinal health. Glutamine is required as fuel for
gastrointestinal cells to reproduce and replace themselves.
It is generally accepted that autoimmune conditions cause the
intestinal lining to become somewhat inflamed and “leaky.” This
leakiness, referred to as increased intestinal permeability, allows for
undigested food particles, bacteria, virus and fungus organisms to make
their way into the blood stream.
Glutamine supplementation can help reduce intestinal permeability
and relieve a variety of inflammatory and autoimmune symptoms
associated with HCV.
Supplementation
An average dose is between 500-3,000 mg, three times per day between meals.
Glutamine is better absorbed when supplemented with vitamin C and vitamin B6.
A dose of only 2 grams/day increases growth hormone levels: this
effect may be important for those with HCV with subnormal growth
hormone levels.
Oral supplementation with glutamine between 2-4 grams per day helps to
restore proper gastrointestinal function, heal gastrointestinal mucosa,
reduce intestinal permeability and improve absorption of foods.
Supplementation may also help to reduce the immunologic load upon the
intestines.
http://www.hopeforhepatitisc.com/HealthyLiving/HepC/Part-8.pdf
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