Comments for Oxygen and Hepatitis C at http://www.hepcaustralia.com.au , comment 1 to 2 out of 2 comments http://www.hepcaustralia.com.au Tue, 06 Jan 2009 21:25:44 +0100 FeedCreator 1.7.3 http://www.hepcaustralia.com.au/index.php/articles/32-ahcs-articles/544-oxygen-and-hepatitis-c#comment-15 The depletion of selenium by HCV and HBV is the primary reason why oxidative stress rises in infected cells. This inceased oxidative tone then impairs the methylation reactions that form SAMe, glycine, carnitine, choline etc., which also depletes SAMe products cysteine, GSH and taurine, and causes fat to accumulate in the hepatocyte. Thiese problems are easily fixed... - George Mon, 30 Jun 2008 19:03:36 +0100 http://www.hepcaustralia.com.au/index.php/articles/32-ahcs-articles/544-oxygen-and-hepatitis-c#comment-14 ATP is needed to make SAMe from methionine - in cirrhosis this reaction fails. As ATP is mostly formed from fatty acid oxidation in mitochondria in hepatocytes, the depletion of carnitine that occurs in the earlier stages of hepatitis is likely to be a primary cause. Thus supporting the transmethylation and transsulfuration pathways early in hepatitis can protect them from the disruption of end-stage liver disease. A stitch in time... - George Mon, 30 Jun 2008 18:58:47 +0100