A recent study using two new drugs, BMS-790052 and BMS-650032, combined with pegylated interferon and ribavirin achieved a 100% sustained virological response in people with chronic hepatitis C. The study involved previous non-responders with genotype 1. In addition, 11 people were treated only with the two new drugs (without pegylated interferon and ribavirin) and of these 4 achieved sustained virological response.

Data from the study was presented by Anna Lok at the International Liver Congress 2011 and was described as a proof of concept that hepatitis C can be cured without interferon and ribavirin.

The study using the NS5A inhibitor BMS-790052 and protease inhibitor BMS-650032 also demonstrated the exciting promise of the quadruple therapy. View slides report to NATAP and read news article on the same subject.

HCV Cured With out Peginterferon/ribavirin with 2 oral HCV drugs BMS790052+BMS650032: Quadruple Therapy With BMS-790052, BMS-650032 and Peg-IFN/RBV for 24 Weeks Results in 100% SVR12 in HCV Genotype 1 Null Responders: "HCV infection can be cured without interferon & ribavirin: 2 orals BMS790052+BMS650032"


Reported by Jules Levin
EASL 2011 April 2 Berlin Germany

Presented by Anna Lok

from Jules: this is the biggest story & news to come out of this meeting, needless to say, and the biggest advancement in medicine in 50 years. In this study 4/11 null-responders receiving BMS-790052 (NS5A inhibitor) + BMS-650032 (protease inhibitor) alone for 24 weeks achieved SVR12 & SVR24. The presentation says "HCV infection can be cured without interferon & ribavirin". BMS-790052 & BMS-650032 with peg/RBV for 24 weeks: 10/10 patients achieved SVR12 & 9/10 achieved SVR24: "QUAD therapy can result in a high rate of cure in this difficult to treat population" (1 patient < LLOQ at week 24 post treatment undetectable on retesting 35 days later). This is the proof of concept we have been waiting for that at least some patients can be cured without peg/rbv, now these are the hardest to treat patients null-responders.

http://www.natap.org/2011/EASL/EASL_28.htm

Go to this link to view more information:
http://www.hepccouncilsa.asn.au/compone ... uadtherapy

---

Add this page to your favourite Social Bookmarking websites;

Set as favorite

Email this

Hits: 572

Comments (0)

Write comment

Name

Email

Comment

smaller | bigger

Subscribe via email (registered users only)

I have read and agree to the Terms of Usage.

Add Comment